PathMap Literature Based Discovery Engine
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Sarcopenia and Amyotrophic Lateral Sclerosis: Biological Pathways and Analysis


The ALS-T2D comorbidity is driven by a bidirectional, exosome-mediated proteostatic collapse. Peripheral tissues (muscle, pancreas) dictate CNS TDP-43 stability via exosomal miRNAs (miR-126a-5p) and glucose-dependent modifications (O-GlcNAcylation). Conversely, pharmacological activation of ubiquitin-peptidases (e.g., Acarbose targeting USP46) or restitution of glycolytic cofactors (F2,6BP) represent novel, cross-disciplinary therapeutic targets capable of halting systemic proteinopathy.


Diabetes Mellitus, Type 2
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Extracellular Vesicles
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DNA-Binding Proteins
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Amyotrophic Lateral Sclerosis
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What kinds of changes in voice occur prior to Amyotrophic Lateral Sclerosis onset?


#PITRM1 #ALS #Microglia #Mitochondria


How does the gut-brain axis play a role in Alzheimer's Disease? Is there a potential link for gut-brain axis for other neurological disorders such as Amyotrophic Lateral Sclerosis?


Dysbiosis
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Intestinal Permeability
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Systemic Inflammatory Response Syndrome
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Neuroinflammation
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Why does Amyotrophic Lateral Sclerosis seem to be on the rise?


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